GB1444529A – Benzodiazepine derivatives
– Google Patents
GB1444529A – Benzodiazepine derivatives
– Google Patents
Benzodiazepine derivatives
Info
Publication number
GB1444529A
GB1444529A
GB2727975A
GB2727975A
GB1444529A
GB 1444529 A
GB1444529 A
GB 1444529A
GB 2727975 A
GB2727975 A
GB 2727975A
GB 2727975 A
GB2727975 A
GB 2727975A
GB 1444529 A
GB1444529 A
GB 1444529A
Authority
GB
United Kingdom
Prior art keywords
formula
june
compound
compounds
benzodiazepine derivatives
Prior art date
1974-06-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2727975A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-06-28
Filing date
1975-06-27
Publication date
1976-08-04
1975-06-27
Application filed by F Hoffmann La Roche AG
filed
Critical
F Hoffmann La Roche AG
1976-08-04
Publication of GB1444529A
publication
Critical
patent/GB1444529A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
C07C271/06—Esters of carbamic acids
C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/08—Antiepileptics; Anticonvulsants
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/20—Hypnotics; Sedatives
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P33/00—Antiparasitic agents
A61P33/10—Anthelmintics
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
C07D243/24—Oxygen atoms
C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
Abstract
1444529 Benzodiazepines F HOFFMANNLA ROCHE & CO AG 27 June 1975 [28 June 1974] 27279/75 Heading C2C 3S-Compounds of the general Formula (I) (R 1 =H, C 1-5 alkyl; R 2 = halogen) are prepared by (a) cyclizing a compound of the Formula (II) or (b) reacting a compound of the Formula (III) with L-alanine or a reactive derivative thereof, optionally followed by alkylation. The preparation of starting materials of Formula (II) and (-)-benzyl 1-[2-(o-chlorobenzoyl)- 4-nitrophenylcarbamoyl]ethylcarbamate is described. The above compounds are anthelmintics, muscle relaxants, anticonvulsants and sedatives, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB2727975A
1974-06-28
1975-06-27
Benzodiazepine derivatives
Expired
GB1444529A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
CH892674A
CH602672A5
(en)
1974-06-28
1974-06-28
Publications (1)
Publication Number
Publication Date
GB1444529A
true
GB1444529A
(en)
1976-08-04
Family
ID=4346371
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB2727975A
Expired
GB1444529A
(en)
1974-06-28
1975-06-27
Benzodiazepine derivatives
Country Status (18)
Country
Link
US
(1)
US4046890A
(en)
JP
(1)
JPS6050786B2
(en)
AT
(1)
AT347468B
(en)
BE
(1)
BE830722A
(en)
CA
(1)
CA1048495A
(en)
CH
(1)
CH602672A5
(en)
DE
(1)
DE2526869A1
(en)
DK
(1)
DK293375A
(en)
FR
(1)
FR2276055A1
(en)
GB
(1)
GB1444529A
(en)
IE
(1)
IE41481B1
(en)
IL
(1)
IL47263A
(en)
KE
(1)
KE3004A
(en)
LU
(1)
LU72837A1
(en)
NL
(1)
NL7507682A
(en)
PH
(1)
PH12433A
(en)
SE
(1)
SE421126B
(en)
ZA
(1)
ZA752965B
(en)
Families Citing this family (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2834637A1
(en)
*
2002-01-15
2003-07-18
Centre Nat Rech Scient
USE OF A NEW CLASS OF MEDICAMENTS FOR THE TREATMENT OF PARASITIC DISEASES
US20090156565A1
(en)
*
2004-12-03
2009-06-18
The Children’s Hospital Of Philadelphia
Composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug
Family Cites Families (8)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3123529A
(en)
*
1964-03-03
-parenteral -compoiaxions -containing
US3121076A
(en)
*
1964-02-11
Benzodiazepinones and processes
US3116203A
(en)
*
1962-03-14
1963-12-31
Hoffmann La Roche
Oleaginous systems
US3248223A
(en)
*
1962-04-11
1966-04-26
Hoffmann La Roche
Animal feeds and methods
GB1056289A
(en)
*
1964-01-14
1967-01-25
Delmar Chem
2-phthalimido acetamido benzophenones and their preparation
FR1462887A
(en)
*
1966-01-06
1966-12-16
Hoffmann La Roche
Process for the preparation of benzodiazepine derivatives
CH554349A
(en)
*
1971-03-17
1974-09-30
Crc Ricerca Chim
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-ONES.
US3998811A
(en)
*
1971-03-17
1976-12-21
Crc Compagnia Di Recerca Chimica S.A.
Optically active 1,4-benzodiazepines and process for the preparation thereof
1974
1974-06-28
CH
CH892674A
patent/CH602672A5/xx
not_active
IP Right Cessation
1975
1975-05-07
ZA
ZA00752965A
patent/ZA752965B/en
unknown
1975-05-09
IL
IL47263A
patent/IL47263A/en
unknown
1975-06-16
DE
DE19752526869
patent/DE2526869A1/en
not_active
Ceased
1975-06-23
IE
IE1388/75A
patent/IE41481B1/en
unknown
1975-06-23
US
US05/589,495
patent/US4046890A/en
not_active
Expired – Lifetime
1975-06-23
SE
SE7507186A
patent/SE421126B/en
not_active
IP Right Cessation
1975-06-23
PH
PH17303A
patent/PH12433A/en
unknown
1975-06-24
JP
JP50077088A
patent/JPS6050786B2/en
not_active
Expired
1975-06-24
FR
FR7519688A
patent/FR2276055A1/en
active
Granted
1975-06-26
LU
LU72837A
patent/LU72837A1/xx
unknown
1975-06-27
DK
DK293375A
patent/DK293375A/en
not_active
Application Discontinuation
1975-06-27
GB
GB2727975A
patent/GB1444529A/en
not_active
Expired
1975-06-27
AT
AT497575A
patent/AT347468B/en
not_active
IP Right Cessation
1975-06-27
BE
BE157744A
patent/BE830722A/en
not_active
IP Right Cessation
1975-06-27
NL
NL7507682A
patent/NL7507682A/en
not_active
Application Discontinuation
1975-06-27
CA
CA75230357A
patent/CA1048495A/en
not_active
Expired
1979
1979-11-16
KE
KE3004A
patent/KE3004A/en
unknown
Also Published As
Publication number
Publication date
IL47263A0
(en)
1975-07-28
PH12433A
(en)
1979-02-22
SE7507186L
(en)
1975-12-29
DE2526869A1
(en)
1976-01-15
JPS5123282A
(en)
1976-02-24
AU8110475A
(en)
1976-11-18
BE830722A
(en)
1975-12-29
CH602672A5
(en)
1978-07-31
US4046890A
(en)
1977-09-06
SE421126B
(en)
1981-11-30
NL7507682A
(en)
1975-12-30
DK293375A
(en)
1975-12-29
IE41481L
(en)
1975-12-28
LU72837A1
(en)
1977-03-07
AT347468B
(en)
1978-12-27
FR2276055B1
(en)
1979-08-17
JPS6050786B2
(en)
1985-11-11
FR2276055A1
(en)
1976-01-23
CA1048495A
(en)
1979-02-13
IL47263A
(en)
1979-03-12
ATA497575A
(en)
1978-05-15
KE3004A
(en)
1979-12-14
IE41481B1
(en)
1980-01-16
ZA752965B
(en)
1976-04-28
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Benzoxadiazocine Derivatives and the Conversion Thereof into Benzodiazepine Derivatives
Legal Events
Date
Code
Title
Description
1976-12-15
PS
Patent sealed [section 19, patents act 1949]
1989-02-15
PCNP
Patent ceased through non-payment of renewal fee
