GB1448026A – 2-aminomethyleneindanone analgesic agents
– Google Patents
GB1448026A – 2-aminomethyleneindanone analgesic agents
– Google Patents
2-aminomethyleneindanone analgesic agents
Info
Publication number
GB1448026A
GB1448026A
GB5483073A
GB5483073A
GB1448026A
GB 1448026 A
GB1448026 A
GB 1448026A
GB 5483073 A
GB5483073 A
GB 5483073A
GB 5483073 A
GB5483073 A
GB 5483073A
GB 1448026 A
GB1448026 A
GB 1448026A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
alkyl
indanone
reaction
indanones
Prior art date
1972-12-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5483073A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1972-12-06
Filing date
1973-11-26
Publication date
1976-09-02
1973-11-26
Application filed by Pfizer Inc
filed
Critical
Pfizer Inc
1976-09-02
Publication of GB1448026A
publication
Critical
patent/GB1448026A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
C07C225/18—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings the carbon skeleton containing also rings other than six-membered aromatic rings
Abstract
1448026 Aminomethylene indanones PFIZER Inc 26 Nov 1973 [6 Dec 1972] 54830/73 Heading C2C Novel compounds of Formula I and the pharmaceutically acceptable acid addition salts thereof, wherein R is hydrogen, C 1 -C 4 alkyl or phenyl; Z is -N(R 3 )R 4 , NH(CH 2 )nN(R 5 )(R 6 or NH(CH 2 ) n OR 3 , wherein R 3 and R 4 are each hydrogen or C 1 -C 4 alkyl, R 5 and R 6 are each hydrogen or C 1 -C 4 alkyl and n is integer of from 1 to 5; R 1 and R 2 are hydrogen or C 1 -C 4 alkyl; R 7 and R 8 are each hydrogen, fluoro or chloro; and R 9 is hydrogen or fluoro are prepared either by reaction of a 2-hydroxymethylene-1-indanone with an appropriate nitrogen compound or reaction of a 1-indanone with RC(O(C 1-2 )alkyl) 2 N(CH 3 ) 2 and optional further reaction of the 2 – dimethylaminomethylene – 1 – indanone with an appropriate nitrogen compound. 2 – Hydroxymethylene – 1 – indanones are prepared by reaction of ethyl formate and sodium methoxide with a suitable indanone. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having analgesic activity comprise an above novel compound and a carrier or diluent.
GB5483073A
1972-12-06
1973-11-26
2-aminomethyleneindanone analgesic agents
Expired
GB1448026A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US05/312,693
US4022836A
(en)
1972-12-06
1972-12-06
2-Aminomethyleneindanone analgesic agents
Publications (1)
Publication Number
Publication Date
GB1448026A
true
GB1448026A
(en)
1976-09-02
Family
ID=23212586
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB5483073A
Expired
GB1448026A
(en)
1972-12-06
1973-11-26
2-aminomethyleneindanone analgesic agents
Country Status (20)
Country
Link
US
(2)
US4022836A
(en)
JP
(1)
JPS5542066B2
(en)
AR
(1)
AR207946A1
(en)
AT
(1)
AT326646B
(en)
BE
(1)
BE808275A
(en)
CA
(1)
CA1002068A
(en)
CH
(1)
CH584677A5
(en)
DE
(1)
DE2360096C2
(en)
DK
(1)
DK139575B
(en)
ES
(1)
ES421167A1
(en)
FR
(1)
FR2209565B1
(en)
GB
(1)
GB1448026A
(en)
IE
(1)
IE38553B1
(en)
IL
(1)
IL43722A
(en)
LU
(1)
LU68950A1
(en)
NL
(1)
NL172057C
(en)
NO
(1)
NO137858C
(en)
PH
(1)
PH10690A
(en)
SE
(1)
SE405851B
(en)
ZA
(1)
ZA739052B
(en)
Families Citing this family (11)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4164514A
(en)
*
1972-12-06
1979-08-14
Pfizer Inc.
2-Aminomethyleneindanone analgesic agents
US4117012A
(en)
*
1972-12-06
1978-09-26
Pfizer Inc.
2-aminomethyleneindanone analgesic agents
US4334085A
(en)
*
1978-09-14
1982-06-08
Standard Oil Company (Indiana)
Transamination process for Mannich products
NZ209534A
(en)
*
1983-09-30
1987-01-23
Surgikos Inc
Antimicrobial fabric for surgical drape
US6369289B1
(en)
2000-07-07
2002-04-09
Tyco Healthcare Group Lp
Method and manufacture of a wound dressing for covering an open wound
ATE445838T1
(en)
2001-07-25
2009-10-15
Raptor Pharmaceutical Inc
COMPOSITIONS AND METHODS FOR MODULATING TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER
EP1889198B1
(en)
2005-04-28
2014-11-26
Proteus Digital Health, Inc.
Pharma-informatics system
MX2009002893A
(en)
2006-09-18
2009-07-10
Raptor Pharmaceutical Inc
Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates.
AU2010216512B2
(en)
2009-02-20
2016-06-30
2-Bbb Medicines B.V.
Glutathione-based drug delivery system
BRPI1011188B1
(en)
2009-05-06
2019-10-15
Laboratory Skin Care, Inc.
DERMAL RELEASE COMPOSITIONS UNDERSTANDING CALCIUM ACTIVE-PHOSPHATE PARTICLE COMPLEXES AND METHODS FOR USING THE SAME
US20120077778A1
(en)
2010-09-29
2012-03-29
Andrea Bourdelais
Ladder-Frame Polyether Conjugates
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3454565A
(en)
*
1966-10-05
1969-07-08
American Cyanamid Co
Novel indanones
1972
1972-12-06
US
US05/312,693
patent/US4022836A/en
not_active
Expired – Lifetime
1973
1973-01-01
AR
AR251362A
patent/AR207946A1/en
active
1973-11-26
GB
GB5483073A
patent/GB1448026A/en
not_active
Expired
1973-11-28
ZA
ZA739052A
patent/ZA739052B/en
unknown
1973-11-29
IL
IL43722A
patent/IL43722A/en
unknown
1973-11-29
IE
IE2160/73A
patent/IE38553B1/en
unknown
1973-12-03
DE
DE2360096A
patent/DE2360096C2/en
not_active
Expired
1973-12-03
CA
CA187,227A
patent/CA1002068A/en
not_active
Expired
1973-12-04
FR
FR7343232A
patent/FR2209565B1/fr
not_active
Expired
1973-12-04
AT
AT1013873A
patent/AT326646B/en
not_active
IP Right Cessation
1973-12-05
NO
NO4652/73A
patent/NO137858C/en
unknown
1973-12-05
NL
NLAANVRAGE7316663,A
patent/NL172057C/en
not_active
IP Right Cessation
1973-12-05
SE
SE7316447A
patent/SE405851B/en
unknown
1973-12-05
PH
PH15292A
patent/PH10690A/en
unknown
1973-12-05
DK
DK657173AA
patent/DK139575B/en
unknown
1973-12-05
CH
CH1704473A
patent/CH584677A5/xx
not_active
IP Right Cessation
1973-12-05
ES
ES421167A
patent/ES421167A1/en
not_active
Expired
1973-12-06
JP
JP13575773A
patent/JPS5542066B2/ja
not_active
Expired
1973-12-06
BE
BE1005561A
patent/BE808275A/en
unknown
1973-12-06
LU
LU68950A
patent/LU68950A1/xx
unknown
1977
1977-01-27
US
US05/763,241
patent/US4064272A/en
not_active
Expired – Lifetime
Also Published As
Publication number
Publication date
AU6302373A
(en)
1975-05-29
JPS5542066B2
(en)
1980-10-28
CH584677A5
(en)
1977-02-15
CA1002068A
(en)
1976-12-21
NO137858C
(en)
1978-05-10
NL172057B
(en)
1983-02-01
NL7316663A
(en)
1974-06-10
IL43722A
(en)
1976-03-31
JPS4986352A
(en)
1974-08-19
DE2360096C2
(en)
1982-07-01
BE808275A
(en)
1974-06-06
IL43722A0
(en)
1974-03-14
NL172057C
(en)
1983-07-01
ES421167A1
(en)
1976-04-01
AT326646B
(en)
1975-12-29
ZA739052B
(en)
1974-10-30
AR207946A1
(en)
1976-11-22
IE38553B1
(en)
1978-04-12
LU68950A1
(en)
1974-07-05
DK139575C
(en)
1979-08-27
IE38553L
(en)
1974-06-06
PH10690A
(en)
1977-08-10
SE405851B
(en)
1979-01-08
US4022836A
(en)
1977-05-10
DK139575B
(en)
1979-03-12
ATA1013873A
(en)
1975-03-15
FR2209565A1
(en)
1974-07-05
DE2360096A1
(en)
1974-07-04
SE7316447L
(en)
1974-06-07
FR2209565B1
(en)
1977-04-08
NO137858B
(en)
1978-01-30
US4064272A
(en)
1977-12-20
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Legal Events
Date
Code
Title
Description
1977-01-13
PS
Patent sealed [section 19, patents act 1949]
1984-08-01
PCNP
Patent ceased through non-payment of renewal fee
