GB1459943A – Heterocyclic esters of alkylphenyl benzopyrans
– Google Patents
GB1459943A – Heterocyclic esters of alkylphenyl benzopyrans
– Google Patents
Heterocyclic esters of alkylphenyl benzopyrans
Info
Publication number
GB1459943A
GB1459943A
GB1485374A
GB1485374A
GB1459943A
GB 1459943 A
GB1459943 A
GB 1459943A
GB 1485374 A
GB1485374 A
GB 1485374A
GB 1485374 A
GB1485374 A
GB 1485374A
GB 1459943 A
GB1459943 A
GB 1459943A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
benzopyrans
alkylphenyl
april
Prior art date
1973-04-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1485374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-04-05
Filing date
1974-04-03
Publication date
1976-12-31
1974-04-03
Application filed by Abbott Laboratories
filed
Critical
Abbott Laboratories
1976-12-31
Publication of GB1459943A
publication
Critical
patent/GB1459943A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
C07D311/78—Ring systems having three or more relevant rings
C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Abstract
1459943 Esters of dibenzopyranols and cyclopentabenzopyranols ABBOTT LABORATORIES 3 April 1974 [5 April 1973 13 Feb 1974] 14853/74 Heading C2C The invention comprises compounds of formulµ and their pharmaceutically acceptable salts, wherein n is 1 or 2, R and R 1 are each H or C 1-6 alkyl, R 2 is C 1-6 alkyl, Y is C 1-10 alkylene, R 4 , R 5 and R 6 are each H, halogen, CF 3 or C 1-6 alkyl, and R 3 is Q-C 2-9 -alkanoyl where Q is an N-attached saturated heterocyclyl radical as defined in the Specification. These compounds are prepared by ester-formation, by reacting together in the presence of dicyclohexylcarbodiimide, the corresponding phenol and carboxylic acid R 3 OH. Therapeutic compositions for oral, parenteral or rectal administration comprise the above compounds, which are analgesics and mild tranquilizers.
GB1485374A
1973-04-05
1974-04-03
Heterocyclic esters of alkylphenyl benzopyrans
Expired
GB1459943A
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US34837173A
1973-04-05
1973-04-05
US05/442,033
US4049653A
(en)
1973-04-05
1974-02-13
Heterocyclic esters of alkylphenyl benzopyrans
Publications (1)
Publication Number
Publication Date
GB1459943A
true
GB1459943A
(en)
1976-12-31
Family
ID=26995674
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB1485374A
Expired
GB1459943A
(en)
1973-04-05
1974-04-03
Heterocyclic esters of alkylphenyl benzopyrans
Country Status (13)
Country
Link
US
(1)
US4049653A
(en)
JP
(1)
JPS5035169A
(en)
AU
(1)
AU476698B2
(en)
CA
(1)
CA1038383A
(en)
CH
(1)
CH592086A5
(en)
DE
(1)
DE2416491C3
(en)
FI
(1)
FI60007C
(en)
FR
(1)
FR2224157B1
(en)
GB
(1)
GB1459943A
(en)
NL
(1)
NL7404147A
(en)
NO
(1)
NO141341C
(en)
PH
(1)
PH13583A
(en)
SE
(1)
SE413191B
(en)
Families Citing this family (8)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2615397A1
(en)
*
1976-04-08
1977-10-27
Sharps Ass
Analgesic benzopyran ester prepn. – from a homopiperidino-alkanoic acid with a cycloalkano-benzopyran deriv
US4133819A
(en)
*
1977-06-17
1979-01-09
Pfizer Inc.
Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
US4243674A
(en)
*
1978-06-12
1981-01-06
Pfizer Inc.
9-Hydroxydibenzo[b,d]pyrans and intermediates therefore
US4454144A
(en)
*
1982-06-21
1984-06-12
Pfizer Inc.
Substituted dibenzo[b,d]pyran analgesics
US5498419A
(en)
*
1994-06-03
1996-03-12
Pars; Harry G.
Fumarate salt of 4-(diethyl-3-(1-methyloctyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, 4-(diethyl-amino) butyric
DE19706903A1
(en)
1997-02-21
1998-08-27
Bayer Ag
Use of known agonists of the central cannabinoid receptor CB 1
US6187203B1
(en)
*
1998-12-01
2001-02-13
Academia Sinica
Sample purification apparatus and method
CN101677931B
(en)
*
2007-03-16
2013-01-02
株式会社资生堂
Wrinkling-preventing and -modifying agent
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3880885A
(en)
*
1971-11-23
1975-04-29
Sandoz Ag
Tertiary aminoethyl isochromans and isocoumarins
US3984419A
(en)
1972-06-21
1976-10-05
E. R. Squibb & Sons, Inc.
Perhydrofluorenetetrol and perhydro-phenanthrenetetrol derivatives
1974
1974-02-13
US
US05/442,033
patent/US4049653A/en
not_active
Expired – Lifetime
1974-03-14
AU
AU66649/74A
patent/AU476698B2/en
not_active
Expired
1974-03-27
NL
NL7404147A
patent/NL7404147A/xx
not_active
Application Discontinuation
1974-03-29
NO
NO741142A
patent/NO141341C/en
unknown
1974-04-01
CA
CA196,458A
patent/CA1038383A/en
not_active
Expired
1974-04-01
SE
SE7404388A
patent/SE413191B/en
unknown
1974-04-02
JP
JP49036719A
patent/JPS5035169A/ja
active
Pending
1974-04-02
PH
PH15684A
patent/PH13583A/en
unknown
1974-04-03
FI
FI1027/74A
patent/FI60007C/en
active
1974-04-03
GB
GB1485374A
patent/GB1459943A/en
not_active
Expired
1974-04-04
DE
DE2416491A
patent/DE2416491C3/en
not_active
Expired
1974-04-04
FR
FR7412012A
patent/FR2224157B1/fr
not_active
Expired
1974-04-05
CH
CH479774A
patent/CH592086A5/xx
not_active
IP Right Cessation
Also Published As
Publication number
Publication date
CA1038383A
(en)
1978-09-12
FI60007C
(en)
1981-11-10
US4049653A
(en)
1977-09-20
NO141341B
(en)
1979-11-12
PH13583A
(en)
1980-07-16
NO741142L
(en)
1974-10-08
JPS5035169A
(en)
1975-04-03
NL7404147A
(en)
1974-10-08
NO141341C
(en)
1980-02-20
AU476698B2
(en)
1976-09-30
DE2416491C3
(en)
1981-01-15
AU6664974A
(en)
1975-09-18
FR2224157A1
(en)
1974-10-31
FR2224157B1
(en)
1977-05-06
FI60007B
(en)
1981-07-31
DE2416491B2
(en)
1979-06-28
CH592086A5
(en)
1977-10-14
SE413191B
(en)
1980-04-28
DE2416491A1
(en)
1974-10-24
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Legal Events
Date
Code
Title
Description
1977-05-18
PS
Patent sealed [section 19, patents act 1949]
1984-12-05
PCNP
Patent ceased through non-payment of renewal fee
