GB1461948A

GB1461948A – 7-substituted-3-amino-alkyl-acylaminoalkyl-or hydroxyalkyl- substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
– Google Patents

GB1461948A – 7-substituted-3-amino-alkyl-acylaminoalkyl-or hydroxyalkyl- substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
– Google Patents
7-substituted-3-amino-alkyl-acylaminoalkyl-or hydroxyalkyl- substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof

Info

Publication number
GB1461948A

GB1461948A
GB1414374A
GB1414374A
GB1461948A
GB 1461948 A
GB1461948 A
GB 1461948A
GB 1414374 A
GB1414374 A
GB 1414374A
GB 1414374 A
GB1414374 A
GB 1414374A
GB 1461948 A
GB1461948 A
GB 1461948A
Authority
GB
United Kingdom
Prior art keywords
substituted
acylaminoalkyl
hydroxyalkyl
carboxylic acid
amino
Prior art date
1973-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB1414374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fujisawa Pharmaceutical Co Ltd

Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-03-30
Filing date
1974-03-29
Publication date
1977-01-19

1973-03-30
Priority claimed from JP48037205A
external-priority
patent/JPS5939439B2/en

1973-06-29
Priority claimed from JP48073898A
external-priority
patent/JPS5852997B2/en

1973-12-12
Priority claimed from JP13936473A
external-priority
patent/JPS5716118B2/ja

1973-12-26
Priority claimed from JP741096A
external-priority
patent/JPS5734837B2/ja

1974-01-30
Priority claimed from JP1308374A
external-priority
patent/JPS5732074B2/ja

1974-03-29
Application filed by Fujisawa Pharmaceutical Co Ltd
filed
Critical
Fujisawa Pharmaceutical Co Ltd

1977-01-19
Publication of GB1461948A
publication
Critical
patent/GB1461948A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

C07D501/14—Compounds having a nitrogen atom directly attached in position 7

C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3

C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

C07D501/36—Methylene radicals, substituted by sulfur atoms

Abstract

Compounds of the formula in which R1 denotes an acyl group, R2 denotes an aminoalkyl-, acylaminoalkyl- or hydroxyalkyl-substituted heterocyclic group containing N or N and S and M denotes a hydrogen atom or a pharmaceutically tolerable cation, are prepared by acylation of corresponding 7-amino compounds with a carboxylic acid R1-OH. The compounds are novel; they display a potent antibacterial action and can be used in infectious diseases.

GB1414374A
1973-03-30
1974-03-29
7-substituted-3-amino-alkyl-acylaminoalkyl-or hydroxyalkyl- substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof

Expired

GB1461948A
(en)

Applications Claiming Priority (5)

Application Number
Priority Date
Filing Date
Title

JP48037205A

JPS5939439B2
(en)

1973-03-30
1973-03-30

Method for producing 7-substituted-3-N,S-containing heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivative

JP48073898A

JPS5852997B2
(en)

1973-06-29
1973-06-29

7- Chikane -3- Hydroxyalkylthikane Fusocanethiomethyl -3- Cefem -4- Carbonsanluino Seizouhou

JP13936473A

JPS5716118B2
(en)

1973-12-12
1973-12-12

JP741096A

JPS5734837B2
(en)

1973-12-26
1973-12-26

JP1308374A

JPS5732074B2
(en)

1974-01-30
1974-01-30

Publications (1)

Publication Number
Publication Date

GB1461948A
true

GB1461948A
(en)

1977-01-19

Family
ID=27518056
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1414374A
Expired

GB1461948A
(en)

1973-03-30
1974-03-29
7-substituted-3-amino-alkyl-acylaminoalkyl-or hydroxyalkyl- substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof

Country Status (10)

Country
Link

AR
(1)

AR207752A1
(en)

BE
(1)

BE812951A
(en)

CH
(3)

CH610902A5
(en)

DE
(1)

DE2415402C2
(en)

FR
(1)

FR2223002B1
(en)

GB
(1)

GB1461948A
(en)

NL
(1)

NL180422C
(en)

NO
(2)

NO741137L
(en)

NZ
(1)

NZ173837A
(en)

SE
(1)

SE428297B
(en)

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4379924A
(en)

1973-12-25
1983-04-12
Takeda Chemical Industries, Ltd.
Cephalosporin derivatives

WO2001044186A1
(en)

*

1999-12-16
2001-06-21
Sumitomo Pharmaceuticals Company, Limited
Substituted guanidine derivatives

Families Citing this family (12)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4093723A
(en)

1976-05-19
1978-06-06
Smithkline Corporation
7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins

BE845338A
(en)

*

1975-09-02
1977-02-21

NEW CEPHALOSPORINS, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL APPLICATION

US4171433A
(en)

*

1975-10-30
1979-10-16
Smithkline Corporation
7-Amino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporin intermediates for preparing 7-acylamino cephalosporins

IL50546A
(en)

*

1975-10-30
1980-07-31
Smithkline Corp
7-acyl-3-(1-(2-sulfaminoethyl)tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions containing them

US4171368A
(en)

*

1975-10-30
1979-10-16
Smithkline Corporation
7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them

US4171362A
(en)

*

1975-10-30
1979-10-16
Smithkline Corporation
7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins antibacterial compositions containing them and methods of treating bacterial infections with them

US4118491A
(en)

*

1976-03-11
1978-10-03
Smithkline Corporation
7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them

US4066762A
(en)

*

1976-07-12
1978-01-03
Smithkline Corporation
Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid

US4101656A
(en)

1976-07-12
1978-07-18
Smithkline Corporation
7β-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them

US4083975A
(en)

1976-09-24
1978-04-11
Smithkline Corporation
7-Acylamino-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

US4064242A
(en)

*

1976-11-04
1977-12-20
Smithkline Corporation
7-Acylamino-3-[1-(2,3-dihydroxypropyl)tetrazole-5-ylthiomethyl]-3-cephem-4-carboxylic acids

US4117123A
(en)

*

1977-06-09
1978-09-26
Smithkline Corporation
7-Acylamino-3-[1-(2-sulfamidoethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3641021A
(en)

*

1969-04-18
1972-02-08
Lilly Co Eli
3 7-(ring-substituted) cephalosporin compounds

DE1953861C2
(en)

*

1969-10-25
1982-12-23
Fujisawa Pharmaceutical Co., Ltd., Osaka

7-tetrazolylacetamido-3-thiomethyl-3-cephem-4-carboxylic acids

US3757014A
(en)

*

1971-05-07
1973-09-04
Bristol Myers Co
Ts 1,3,4 – oxadiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid and sal7-(d-(alpha-amino-alpha-pheyle-acetamido)) – 3-(s-(5-hydroxymethyl –

CA999574A
(en)

1972-06-14
1976-11-09
Smith Kline And French Canada Ltd.
7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins

1974

1974-01-01
AR
AR253054A
patent/AR207752A1/en
active

1974-03-28
BE
BE142549A
patent/BE812951A/en
not_active
IP Right Cessation

1974-03-29
NO
NO741137A
patent/NO741137L/en
unknown

1974-03-29
CH
CH963877A
patent/CH610902A5/en
not_active
IP Right Cessation

1974-03-29
CH
CH963977A
patent/CH610903A5/en
not_active
IP Right Cessation

1974-03-29
GB
GB1414374A
patent/GB1461948A/en
not_active
Expired

1974-03-29
SE
SE7404306A
patent/SE428297B/en
unknown

1974-03-29
NL
NLAANVRAGE7404330,A
patent/NL180422C/en
not_active
IP Right Cessation

1974-03-29
NZ
NZ173837A
patent/NZ173837A/en
unknown

1974-03-29
DE
DE2415402A
patent/DE2415402C2/en
not_active
Expired

1974-03-29
CH
CH442874A
patent/CH595388A5/xx
not_active
IP Right Cessation

1974-03-29
FR
FR7411408A
patent/FR2223002B1/fr
not_active
Expired

1980

1980-05-12
NO
NO80801402A
patent/NO801402L/en
unknown

Cited By (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4379924A
(en)

1973-12-25
1983-04-12
Takeda Chemical Industries, Ltd.
Cephalosporin derivatives

WO2001044186A1
(en)

*

1999-12-16
2001-06-21
Sumitomo Pharmaceuticals Company, Limited
Substituted guanidine derivatives

US6734205B2
(en)

1999-12-16
2004-05-11
Sumitomo Pharmaceuticals Company Limited
Substituted guanidine derivatives

Also Published As

Publication number
Publication date

NO801402L
(en)

1974-10-01

FR2223002B1
(en)

1977-11-04

NZ173837A
(en)

1978-07-28

NL180422C
(en)

1987-02-16

BE812951A
(en)

1974-09-30

AR207752A1
(en)

1976-10-29

CH610902A5
(en)

1979-05-15

NL7404330A
(en)

1974-10-02

CH595388A5
(en)

1978-02-15

NO741137L
(en)

1974-10-01

NL180422B
(en)

1986-09-16

FR2223002A1
(en)

1974-10-25

SE428297B
(en)

1983-06-20

AU6735374A
(en)

1975-10-02

DE2415402A1
(en)

1974-10-03

CH610903A5
(en)

1979-05-15

DE2415402C2
(en)

1985-12-19

SE7404306L
(en)

1974-10-01

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Legal Events

Date
Code
Title
Description

1977-06-01
PS
Patent sealed [section 19, patents act 1949]

1989-11-29
PCNP
Patent ceased through non-payment of renewal fee

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