GB1476793A – Nondestructively analysing biological cells using opto- electrical apparatus
– Google Patents
GB1476793A – Nondestructively analysing biological cells using opto- electrical apparatus
– Google Patents
Nondestructively analysing biological cells using opto- electrical apparatus
Info
Publication number
GB1476793A
GB1476793A
GB4477374A
GB4477374A
GB1476793A
GB 1476793 A
GB1476793 A
GB 1476793A
GB 4477374 A
GB4477374 A
GB 4477374A
GB 4477374 A
GB4477374 A
GB 4477374A
GB 1476793 A
GB1476793 A
GB 1476793A
Authority
GB
United Kingdom
Prior art keywords
light
cell
signal
filter
amplifier
Prior art date
1973-10-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4477374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coulter Electronics Inc
Original Assignee
Coulter Electronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-10-23
Filing date
1974-10-16
Publication date
1977-06-16
1974-10-16
Application filed by Coulter Electronics Inc
filed
Critical
Coulter Electronics Inc
1977-06-16
Publication of GB1476793A
publication
Critical
patent/GB1476793A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
G—PHYSICS
G01—MEASURING; TESTING
G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
G01N15/10—Investigating individual particles
G01N15/14—Electro-optical investigation, e.g. flow cytometers
G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
G—PHYSICS
G01—MEASURING; TESTING
G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
Abstract
1476793 Blood cell analyzer COULTER ELECTRONICS Inc 16 Oct 1974 [23 Oct 1973] 44773/74 Heading G1A Apparatus for analyzing biological cells comprises means for illuminating at least part of each cell with light which includes at least light in a first narrow waverange, means for detecting discretely the amount of light in said narrow waverange from each cell part after absorption thereby, and means connected to it for generating a tag signal indicating the fixed location of each cell for which said amount of light is above or below a threshold value. In the embodiment of Fig. 1, light, including that of wavelength 415 nm, from flying spot scanner 12, is directed to slide 16 with a biological cell sample. Filter 20 passes light of approximately 415 nm and reflects the rest. Filter 30 passes only yellow and reflects blue. Thus photocells 22, 32 and 40 detect 415 nm, yellow and blue light respectively and photo-cell 47 provides a source average brightness signal causing on lead 54 a voltage as both a control for variable gain amplifiers 38 and 46 to compensate for brightness fluctuation and a threshold for comparator 28. If the signal from amplifier 26 falls below this, amplifier 56 receives a tag signal and gives an inhibit signal to cause electronic switches 58 and 60 to couple a voltage representative of background from potentiometer 62 to their outputs, to which they otherwise couple the outputs from amplifiers 38 and 46. Thus the images of red blood cells, which absorb light of 415 nm, are eliminated from the video processor. In the embodiment of Fig. 2 pulsed broadband light from source 66, passes through filter 68, transmitting a narrow band around 415 nm, and the slide 70 to Vidicon 74, controlled by circuitry 78. Comparator 82 gives a tag signal, when the signal from amplifier 80 is below that from potentiometer 84, to memory 86, which also stores XY co-ordinates at that instant. Motor 87 removes filter 68 substituting another and causes switch 88 to connect amplifier 80 via analogue to digital converter 90, which is optional, to gate 94, from which video processor 98 thus receives signals except at those XY co-ordinates for which it is inhibited by a tag signal on line 96. Processor 98 can store information. If reticulocytes are differentiated from erythrocytes using a supravital stain and a filter 106 passing 530 nm is used, density analysis computer 100, activitated by the tag signal on line 104, can produce density/number histograms to determine the percentage of reticulocytes in red blood cells.
GB4477374A
1973-10-23
1974-10-16
Nondestructively analysing biological cells using opto- electrical apparatus
Expired
GB1476793A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US408817A
US3893767A
(en)
1973-10-23
1973-10-23
Electro-optical system for cancellation of the effects of red blood cells in a sample of biological cells
Publications (1)
Publication Number
Publication Date
GB1476793A
true
GB1476793A
(en)
1977-06-16
Family
ID=23617891
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB4477374A
Expired
GB1476793A
(en)
1973-10-23
1974-10-16
Nondestructively analysing biological cells using opto- electrical apparatus
Country Status (10)
Country
Link
US
(1)
US3893767A
(en)
JP
(1)
JPS5433758B2
(en)
CA
(1)
CA1018796A
(en)
CH
(1)
CH592877A5
(en)
DE
(1)
DE2450112C3
(en)
FR
(1)
FR2248509B1
(en)
GB
(1)
GB1476793A
(en)
IT
(1)
IT1024317B
(en)
NL
(1)
NL7413572A
(en)
SE
(1)
SE404259B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
GB2187281A
(en)
*
1986-02-26
1987-09-03
Analytical Instr Ltd
Colour analyser
Families Citing this family (11)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
JPS5916667B2
(en)
*
1975-02-28
1984-04-17
トウアイヨウデンシ カブシキガイシヤ
automatic blood analyzer
US4095898A
(en)
*
1976-06-10
1978-06-20
Coulter Electronics, Inc.
Particle analysis system with photochromic filter
US4097845A
(en)
*
1976-11-01
1978-06-27
Rush-Presbyterian-St. Luke’s Medical Center
Method of and an apparatus for automatic classification of red blood cells
DE3014563A1
(en)
*
1980-04-16
1981-10-29
Merck Patent Gmbh, 6100 Darmstadt
METHOD FOR DETERMINING LEUKAEMIC CELLS
FR2515352B1
(en)
*
1981-10-22
1987-07-17
Int Remote Imaging Systems Inc
METHOD FOR THE ANALYSIS OF PARTICLES CONTAINED IN A SAMPLE OF A DILUTED FLUID
US5272081A
(en)
*
1982-05-10
1993-12-21
Bar-Ilan University
System and methods for cell selection
US5310674A
(en)
*
1982-05-10
1994-05-10
Bar-Ilan University
Apertured cell carrier
US4672038A
(en)
*
1984-10-19
1987-06-09
Abbott Laboratories
Optical readout for blood sample analysis
JPS63275323A
(en)
*
1987-05-08
1988-11-14
Hamamatsu Photonics Kk
Diagnostic apparatus
US9135547B2
(en)
*
2008-12-19
2015-09-15
Avery Dennison Corporation
Optical control of RFID chips
FR3034520B1
(en)
2015-04-02
2020-02-14
Horiba Abx Sas
PARTICLE COUNTING DEVICE
Family Cites Families (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US2875666A
(en)
*
1953-07-13
1959-03-03
Ohio Commw Eng Co
Method of simultaneously counting red and white blood cells
US3315229A
(en)
*
1963-12-31
1967-04-18
Ibm
Blood cell recognizer
US3413464A
(en)
*
1965-04-29
1968-11-26
Ibm
Method for measuring the nucleic acid in biological cells after enhancement in an acidic solution
US3560754A
(en)
*
1965-11-17
1971-02-02
Ibm
Photoelectric particle separator using time delay
US3503684A
(en)
*
1966-11-09
1970-03-31
Perkin Elmer Corp
Method and apparatus for detecting mitotic blood cells on a blood cell sample slide
1973
1973-10-23
US
US408817A
patent/US3893767A/en
not_active
Expired – Lifetime
1974
1974-10-16
JP
JP11830074A
patent/JPS5433758B2/ja
not_active
Expired
1974-10-16
CA
CA211,564A
patent/CA1018796A/en
not_active
Expired
1974-10-16
SE
SE7413014A
patent/SE404259B/en
unknown
1974-10-16
NL
NL7413572A
patent/NL7413572A/en
not_active
Application Discontinuation
1974-10-16
GB
GB4477374A
patent/GB1476793A/en
not_active
Expired
1974-10-16
IT
IT53571/74A
patent/IT1024317B/en
active
1974-10-16
FR
FR7434788A
patent/FR2248509B1/fr
not_active
Expired
1974-10-16
CH
CH1385174A
patent/CH592877A5/xx
not_active
IP Right Cessation
1974-10-22
DE
DE2450112A
patent/DE2450112C3/en
not_active
Expired
Cited By (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
GB2187281A
(en)
*
1986-02-26
1987-09-03
Analytical Instr Ltd
Colour analyser
GB2187281B
(en)
*
1986-02-26
1990-04-04
Analytical Instr Ltd
Colour analyser
Also Published As
Publication number
Publication date
SE7413014L
(en)
1975-04-24
NL7413572A
(en)
1975-04-25
CH592877A5
(en)
1977-11-15
DE2450112A1
(en)
1975-05-22
JPS5433758B2
(en)
1979-10-23
DE2450112C3
(en)
1981-01-15
FR2248509A1
(en)
1975-05-16
DE2450112B2
(en)
1980-04-10
CA1018796A
(en)
1977-10-11
IT1024317B
(en)
1978-06-20
US3893767A
(en)
1975-07-08
FR2248509B1
(en)
1980-09-12
JPS5068588A
(en)
1975-06-07
SE404259B
(en)
1978-09-25
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Legal Events
Date
Code
Title
Description
1977-10-26
PS
Patent sealed [section 19, patents act 1949]
1987-06-03
PCNP
Patent ceased through non-payment of renewal fee
