GB1481813A – Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
– Google Patents
GB1481813A – Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
– Google Patents
Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
Info
Publication number
GB1481813A
GB1481813A
GB46842/74A
GB4684274A
GB1481813A
GB 1481813 A
GB1481813 A
GB 1481813A
GB 46842/74 A
GB46842/74 A
GB 46842/74A
GB 4684274 A
GB4684274 A
GB 4684274A
GB 1481813 A
GB1481813 A
GB 1481813A
Authority
GB
United Kingdom
Prior art keywords
formula
group
substituted
pharmaceutical compositions
hydrogen atom
Prior art date
1973-12-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46842/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-12-14
Filing date
1974-10-29
Publication date
1977-08-03
1974-10-29
Application filed by Shionogi and Co Ltd
filed
Critical
Shionogi and Co Ltd
1977-08-03
Publication of GB1481813A
publication
Critical
patent/GB1481813A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D277/24—Radicals substituted by oxygen atoms
Abstract
1481813 Substituted thiazolidinylidene acetophenones and their pharmaceutical compositions SHIONOGI & CO Ltd 29 Oct 1974 [14 Dec 1973] 46842/74 Heading C2C The invention comprises compounds of Formula I in which R 1 is a C 1-5 alkyl, C 1-5 alkenyl or C 1-5 alkynyl group, an aralkyl group of 7-9 carbon atoms or a (4-amino-2-methyl-5-pyrimidinyl)- methyl group; R 2 is a hydrogen atom or a C 1-5 alkyl group; R 3 is a hydrogen atom or an aryl group and R 4 is a substituted or unsubstituted C 6-10 aryl group which may be prepared by reacting a salt of Formula II wherein R 1 , R 2 and R 3 are as above and X is an acid anion, with a dialkyl aroyl phosphonate of formula in which R 4 is as defined above and R 5 is a C 1-5 alkyl group in the presence of a basic catalyst. Pharmaceutical compositions having analgesic and anti-inflammatory activity for oral or parenteral administration comprise a compound of Formula I together with a pharmaceutically acceptable diluent, carrier or excipient.
GB46842/74A
1973-12-14
1974-10-29
Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
Expired
GB1481813A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
JP48140766A
JPS5089367A
(en)
1973-12-14
1973-12-14
Publications (1)
Publication Number
Publication Date
GB1481813A
true
GB1481813A
(en)
1977-08-03
Family
ID=15276234
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB46842/74A
Expired
GB1481813A
(en)
1973-12-14
1974-10-29
Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
Country Status (15)
Country
Link
US
(1)
US3928327A
(en)
JP
(1)
JPS5089367A
(en)
BE
(1)
BE823354A
(en)
CA
(1)
CA1034575A
(en)
DD
(1)
DD115677A5
(en)
DE
(1)
DE2458933A1
(en)
DK
(1)
DK652374A
(en)
ES
(1)
ES431595A1
(en)
FR
(1)
FR2254339A1
(en)
GB
(1)
GB1481813A
(en)
HU
(1)
HU172089B
(en)
IL
(1)
IL46000A
(en)
NL
(1)
NL7415915A
(en)
SE
(1)
SE7415611L
(en)
ZA
(1)
ZA746315B
(en)
Families Citing this family (12)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US8841334B2
(en)
*
2006-05-31
2014-09-23
Abbvie Inc.
Compounds as cannabinoid receptor ligands and uses thereof
CA2647598A1
(en)
*
2006-05-31
2007-12-06
Abbott Laboratories
Compounds as cannabinoid receptor ligands and uses thereof
WO2008063781A2
(en)
*
2006-10-12
2008-05-29
Abbott Laboratories
Chemical compounds as cannabinoid receptor ligands
MX2009010363A
(en)
2007-03-28
2009-12-04
Abbott Lab
1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands.
US7872033B2
(en)
*
2007-04-17
2011-01-18
Abbott Laboratories
Compounds as cannabinoid receptor ligands
MX2009012374A
(en)
*
2007-05-18
2009-12-01
Abbott Lab
Novel compounds as cannabinoid receptor ligands.
US9193713B2
(en)
*
2007-10-12
2015-11-24
Abbvie Inc.
Compounds as cannabinoid receptor ligands
US8846730B2
(en)
*
2008-09-08
2014-09-30
Abbvie Inc.
Compounds as cannabinoid receptor ligands
US8859596B2
(en)
*
2008-09-16
2014-10-14
Abbvie Inc.
Compounds as cannabinoid receptor ligands
PA8854001A1
(en)
*
2008-12-16
2010-07-27
Abbott Lab
NEW COMPOUNDS AS CANABINOID RECEIVERS LIGANDS
CA2756178A1
(en)
*
2009-03-27
2010-09-30
Abbott Laboratories
Compounds as cannabinoid receptor ligands
JP6531330B2
(en)
*
2013-12-18
2019-06-19
国立大学法人京都大学
Compounds and pharmaceutical compositions related to pain
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3536727A
(en)
*
1966-12-22
1970-10-27
Wyeth John & Brother Ltd
Alpha-(2-arylthiazol-4-yl) lower fatty acids and derivatives
GB1345148A
(en)
*
1970-09-30
1974-01-30
Lilly Industries Ltd
Thiazolo pyrimidinones pyrimidinobenzothiazolones and derivatives thereof
1973
1973-12-14
JP
JP48140766A
patent/JPS5089367A/ja
active
Pending
1974
1974-09-24
US
US509354A
patent/US3928327A/en
not_active
Expired – Lifetime
1974-09-26
CA
CA210,099A
patent/CA1034575A/en
not_active
Expired
1974-10-03
ZA
ZA00746315A
patent/ZA746315B/en
unknown
1974-10-29
GB
GB46842/74A
patent/GB1481813A/en
not_active
Expired
1974-11-02
ES
ES431595A
patent/ES431595A1/en
not_active
Expired
1974-11-05
IL
IL46000A
patent/IL46000A/en
unknown
1974-11-06
FR
FR7436869A
patent/FR2254339A1/fr
not_active
Withdrawn
1974-12-06
NL
NL7415915A
patent/NL7415915A/en
not_active
Application Discontinuation
1974-12-12
SE
SE7415611A
patent/SE7415611L/xx
unknown
1974-12-12
HU
HU74SI00001442A
patent/HU172089B/en
unknown
1974-12-12
DE
DE19742458933
patent/DE2458933A1/en
active
Pending
1974-12-12
DD
DD182973A
patent/DD115677A5/xx
unknown
1974-12-13
DK
DK652374A
patent/DK652374A/da
unknown
1974-12-13
BE
BE151509A
patent/BE823354A/en
unknown
Also Published As
Publication number
Publication date
BE823354A
(en)
1975-04-01
FR2254339A1
(en)
1975-07-11
IL46000A0
(en)
1975-02-10
CA1034575A
(en)
1978-07-11
DE2458933A1
(en)
1975-06-26
US3928327A
(en)
1975-12-23
SE7415611L
(en)
1975-06-16
IL46000A
(en)
1978-04-30
ZA746315B
(en)
1975-11-26
NL7415915A
(en)
1975-06-17
ES431595A1
(en)
1976-11-16
DK652374A
(en)
1975-08-18
JPS5089367A
(en)
1975-07-17
DD115677A5
(en)
1975-10-12
HU172089B
(en)
1978-05-28
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Legal Events
Date
Code
Title
Description
1977-12-14
PS
Patent sealed [section 19, patents act 1949]
1980-06-18
PCNP
Patent ceased through non-payment of renewal fee
