GB1516442A – Osmotically driven dispenser and process for making same
– Google Patents
GB1516442A – Osmotically driven dispenser and process for making same
– Google Patents
Osmotically driven dispenser and process for making same
Info
Publication number
GB1516442A
GB1516442A
GB33834/76A
GB3383476A
GB1516442A
GB 1516442 A
GB1516442 A
GB 1516442A
GB 33834/76 A
GB33834/76 A
GB 33834/76A
GB 3383476 A
GB3383476 A
GB 3383476A
GB 1516442 A
GB1516442 A
GB 1516442A
Authority
GB
United Kingdom
Prior art keywords
agent
dispensing
dispenser
fluid
composition
Prior art date
1975-09-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33834/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1975-09-11
Filing date
1976-08-13
Publication date
1978-07-05
1976-08-13
Application filed by Alza Corp
filed
Critical
Alza Corp
1978-07-05
Publication of GB1516442A
publication
Critical
patent/GB1516442A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K9/00—Medicinal preparations characterised by special physical form
A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K9/00—Medicinal preparations characterised by special physical form
A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
A61K9/0007—Effervescent
Abstract
1516442 Dispensing liquids by osmosis and gas pressure ALZA CORP 13 Aug 1976 [11 Sept 1975] 33834/76 Heading A5B [Also in Divisions B1 and Fl] A dispenser e.g. a buccal tablet 10, for dispensing an active agent composition 15 to a fluid-containing environment, comprises a wall 12 defining a compartment 13 which contains a mixture of the agent composition 15 and a gas-generating composition 16 which is activated by contact with the fluid. The wall 12 has a passage 14 for dispensing the agent and is made of a material that maintains its integrity during dispensing but is permeable to the fluid and impermeable to the agent 15 and gas-generating composition 16. At least one of the compositions 15, 16; or a further compound added to the mixture, is soluble in the fluid and, when in solution, creates an osmotic pressure gradient across the wall so that fluid is drawn into the compartment 13 to cause gas generation and therefore enhanced displacement of the agent from the dispenser 10. The mixture also may contain a surfactant to assist wetting and a foaming agent to aid dispensing. The dispenser may take the form of a parallelelepiped having two passages 14 (Figs. 2A, B, not shown) or a cartridge having a tapered passage 14 (Fig. 3, not shown), the latter type being suitable for dispensing a medicinal agent 15 into a body opening. Generally, however, the active agent 15 may be any composition that is dispensed to produce a useful result. The gasgenerating composition 16 is typically an effervescent couple such as an acid-base mixture, and several suitable chemicals are listed. Various suitable materials for all the components of the dispenser are described, as are processes for making the dispenser. Six examples are detailed. Typically, the ingredients may be mixed and compressed into a tablet which is then coated with the material to form the wall 12, the passage 14 being made by mechanical drilling.
GB33834/76A
1975-09-11
1976-08-13
Osmotically driven dispenser and process for making same
Expired
GB1516442A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US05/612,465
US4036228A
(en)
1975-09-11
1975-09-11
Osmotic dispenser with gas generating means
Publications (1)
Publication Number
Publication Date
GB1516442A
true
GB1516442A
(en)
1978-07-05
Family
ID=24453276
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB33834/76A
Expired
GB1516442A
(en)
1975-09-11
1976-08-13
Osmotically driven dispenser and process for making same
Country Status (12)
Country
Link
US
(1)
US4036228A
(en)
JP
(1)
JPS6035169B2
(en)
AU
(1)
AU500443B2
(en)
CA
(1)
CA1047874A
(en)
CH
(1)
CH620121A5
(en)
DE
(1)
DE2640904A1
(en)
FR
(1)
FR2323440A1
(en)
GB
(1)
GB1516442A
(en)
IE
(1)
IE44451B1
(en)
IT
(1)
IT1068749B
(en)
MX
(1)
MX146684A
(en)
SE
(1)
SE429101B
(en)
Cited By (4)
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Priority date
Publication date
Assignee
Title
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(en)
*
1982-06-22
1984-01-11
Univ Glasgow
Device for introducing nutrients and/or therapeutic materials into ruminant animals
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1983-12-01
1985-07-03
Alza Corp
Constant rate release systems
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1985-08-16
1987-02-25
Alza Corp
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2009-12-31
2012-05-23
Ranbaxy Laboratories Limited
A stable aspirin tablet and process of preparation thereof
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1976-11-22
1980-05-20
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1978-09-05
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1978-09-05
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Osmotic system for delivering selected beneficial agents having varying degrees of solubility
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1978-09-05
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1980-04-25
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Method of delivering drug with aid of effervescent activity generated in environment of use
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GB
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IE
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DE19762640904
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active
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FR
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Also Published As
Publication number
Publication date
JPS5233886A
(en)
1977-03-15
MX146684A
(en)
1982-07-28
IE44451L
(en)
1977-03-11
IT1068749B
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1985-03-21
IE44451B1
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1981-12-02
JPS6035169B2
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1985-08-13
FR2323440B1
(en)
1978-05-05
FR2323440A1
(en)
1977-04-08
DE2640904A1
(en)
1977-03-24
AU1706976A
(en)
1978-03-02
SE429101B
(en)
1983-08-15
AU500443B2
(en)
1979-05-24
DE2640904C2
(en)
1989-01-26
CH620121A5
(en)
1980-11-14
CA1047874A
(en)
1979-02-06
US4036228A
(en)
1977-07-19
SE7609405L
(en)
1977-03-12
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Legal Events
Date
Code
Title
Description
1978-11-01
PS
Patent sealed [section 19, patents act 1949]
1995-04-12
PCNP
Patent ceased through non-payment of renewal fee
Effective date:
19940813
