GB1528738A

GB1528738A – Isoquinolines and their preparation
– Google Patents

GB1528738A – Isoquinolines and their preparation
– Google Patents
Isoquinolines and their preparation

Info

Publication number
GB1528738A

GB1528738A
GB24508/77A
GB2450877A
GB1528738A
GB 1528738 A
GB1528738 A
GB 1528738A
GB 24508/77 A
GB24508/77 A
GB 24508/77A
GB 2450877 A
GB2450877 A
GB 2450877A
GB 1528738 A
GB1528738 A
GB 1528738A
Authority
GB
United Kingdom
Prior art keywords
prepared
substituted
benzoyl
june
hydrolysis
Prior art date
1976-06-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB24508/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1976-06-14
Filing date
1977-06-13
Publication date
1978-10-18

1977-06-13
Application filed by Merck Patent GmbH
filed
Critical
Merck Patent GmbH

1978-10-18
Publication of GB1528738A
publication
Critical
patent/GB1528738A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

1528738 1-Substituted isoquinolines MERCK PATENT GmbH 13 June 1977 [14 June 1976] 24508/77 Heading C2C Novel compounds of the Formula I wherein R1 is H or C 1-4 alkyl, R2 is H and R3 is OH and R2 and R3 together form a C-C bond, and their physiologically acceptable acid addition salts may be prepared by hydrolysis or hydrogenolysis to remove hydrolysable or hydrogenolyseable groups R3 and/or R1 optionally followed, if desired and appropriate, by dehydration of compounds I in which R3 is OH and R 2 is H and/or alkylation to introduce groups at R1, and formation of physiologically acceptable acid addition salts. Various R 1 substituted-4-benzoyloxy-4-(1-isoquinoyl)-piperidines are prepared by reacting 1-cyano-2-benzoyl-1,2-dihydroisoquinoline with the appropriate 1-substituted piperidine-4-one in the presence of base. 1 – Benzyl – 4 – (1 – isoquinolyl) – piperidin – 4 – ol is prepared by hydrolysis of corresponding 4-benzoyl-oxyester. Pharmaceutical compositions of the compound I with the usual excipients show antidepressant activity when administered enterally, parenterally or topically.

GB24508/77A
1976-06-14
1977-06-13
Isoquinolines and their preparation

Expired

GB1528738A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE19762626629

DE2626629A1
(en)

1976-06-14
1976-06-14

ISOCHINOLINE AND THE METHOD OF MANUFACTURING IT

Publications (1)

Publication Number
Publication Date

GB1528738A
true

GB1528738A
(en)

1978-10-18

Family
ID=5980513
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB24508/77A
Expired

GB1528738A
(en)

1976-06-14
1977-06-13
Isoquinolines and their preparation

Country Status (14)

Country
Link

US
(1)

US4122180A
(en)

JP
(1)

JPS52153974A
(en)

BE
(1)

BE855631A
(en)

CA
(1)

CA1073910A
(en)

CH
(1)

CH633793A5
(en)

DE
(1)

DE2626629A1
(en)

ES
(1)

ES459756A1
(en)

FR
(1)

FR2355014A1
(en)

GB
(1)

GB1528738A
(en)

HU
(1)

HU173495B
(en)

IT
(1)

IT1078496B
(en)

NL
(1)

NL7706541A
(en)

SE
(1)

SE7706823L
(en)

ZA
(1)

ZA773571B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0110372A1
(en)

*

1982-12-02
1984-06-13
Hoechst Aktiengesellschaft
1-Phenylisoquinoline derivatives, process for their preparation, pharmaceutical compositions containing these compounds and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3479358A
(en)

*

1966-09-19
1969-11-18
Warner Lambert Pharmaceutical
Hexahydro-9,4a – iminoethano-4a-h-xanthenes and process for their production

US3901897A
(en)

*

1972-10-05
1975-08-26
Squibb & Sons Inc
1,2,3,4,4a,5,6,7-octahydro-7-aryl-isoquinolines and derivatives thereof

GB1488411A
(en)

*

1975-01-16
1977-10-12
Wyeth John & Brother Ltd
3,4-dihydro-4-arylquinolin-4-ol derivatives

1976

1976-06-14
DE
DE19762626629
patent/DE2626629A1/en
not_active
Withdrawn

1977

1977-06-09
FR
FR7717713A
patent/FR2355014A1/en
active
Granted

1977-06-10
CA
CA280,267A
patent/CA1073910A/en
not_active
Expired

1977-06-13
BE
BE178393A
patent/BE855631A/en
not_active
IP Right Cessation

1977-06-13
HU
HU77ME2078A
patent/HU173495B/en
unknown

1977-06-13
US
US05/806,240
patent/US4122180A/en
not_active
Expired – Lifetime

1977-06-13
GB
GB24508/77A
patent/GB1528738A/en
not_active
Expired

1977-06-13
CH
CH724777A
patent/CH633793A5/en
not_active
IP Right Cessation

1977-06-13
IT
IT49799/77A
patent/IT1078496B/en
active

1977-06-13
SE
SE7706823A
patent/SE7706823L/en
not_active
Application Discontinuation

1977-06-14
JP
JP7094277A
patent/JPS52153974A/en
active
Pending

1977-06-14
NL
NL7706541A
patent/NL7706541A/en
not_active
Application Discontinuation

1977-06-14
ZA
ZA00773571A
patent/ZA773571B/en
unknown

1977-06-14
ES
ES459756A
patent/ES459756A1/en
not_active
Expired

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0110372A1
(en)

*

1982-12-02
1984-06-13
Hoechst Aktiengesellschaft
1-Phenylisoquinoline derivatives, process for their preparation, pharmaceutical compositions containing these compounds and their use

US4547508A
(en)

*

1982-12-02
1985-10-15
Hoechst Aktiengesellschaft
1-Phenylisoquinoline derivatives, pharmaceutical products containing these compounds and their use

Also Published As

Publication number
Publication date

FR2355014B1
(en)

1981-01-09

SE7706823L
(en)

1977-12-15

IT1078496B
(en)

1985-05-08

US4122180A
(en)

1978-10-24

DE2626629A1
(en)

1977-12-22

FR2355014A1
(en)

1978-01-13

HU173495B
(en)

1979-05-28

CH633793A5
(en)

1982-12-31

ES459756A1
(en)

1978-10-01

CA1073910A
(en)

1980-03-18

JPS52153974A
(en)

1977-12-21

NL7706541A
(en)

1977-12-16

BE855631A
(en)

1977-12-13

ZA773571B
(en)

1978-05-30

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Legal Events

Date
Code
Title
Description

1979-03-07
PS
Patent sealed [section 19, patents act 1949]

1985-02-06
PCNP
Patent ceased through non-payment of renewal fee

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