GB1528796A

GB1528796A – 7alpha-hydroxyoestradiols
– Google Patents

GB1528796A – 7alpha-hydroxyoestradiols
– Google Patents
7alpha-hydroxyoestradiols

Info

Publication number
GB1528796A

GB1528796A
GB41798/75A
GB4179875A
GB1528796A
GB 1528796 A
GB1528796 A
GB 1528796A
GB 41798/75 A
GB41798/75 A
GB 41798/75A
GB 4179875 A
GB4179875 A
GB 4179875A
GB 1528796 A
GB1528796 A
GB 1528796A
Authority
GB
United Kingdom
Prior art keywords
prepared
estratrien
acyl
oct
hydroxy
Prior art date
1974-10-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB41798/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-10-14
Filing date
1975-10-13
Publication date
1978-10-18

1974-10-14
Priority claimed from DE2449327A
external-priority
patent/DE2449327C2/en

1975-08-08
Priority claimed from DE19752535997
external-priority
patent/DE2535997A1/en

1975-10-13
Application filed by Schering AG
filed
Critical
Schering AG

1978-10-18
Publication of GB1528796A
publication
Critical
patent/GB1528796A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

C07J1/0051—Estrane derivatives

C07J1/0059—Estrane derivatives substituted in position 17 by a keto group

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

C07J1/0051—Estrane derivatives

C07J1/0081—Substituted in position 17 alfa and 17 beta

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

C07J1/0051—Estrane derivatives

C07J1/0081—Substituted in position 17 alfa and 17 beta

C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group

C07J1/0096—Alkynyl derivatives

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC

Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S435/00—Chemistry: molecular biology and microbiology

Y10S435/8215—Microorganisms

Y10S435/911—Microorganisms using fungi

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC

Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S435/00—Chemistry: molecular biology and microbiology

Y10S435/8215—Microorganisms

Y10S435/911—Microorganisms using fungi

Y10S435/912—Absidia

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC

Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S435/00—Chemistry: molecular biology and microbiology

Y10S435/8215—Microorganisms

Y10S435/911—Microorganisms using fungi

Y10S435/913—Aspergillus

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC

Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S435/00—Chemistry: molecular biology and microbiology

Y10S435/8215—Microorganisms

Y10S435/911—Microorganisms using fungi

Y10S435/939—Rhizopus

Abstract

1528796 7α-Hydroxy-cotradiols SCHERING AG 13 Oct 1975 [14 Oct 1974 8 Aug 1975] 41798/75 Heading C2U Novel steroids of the formula (wherein R 1 is H, acyl, optionally substituted alkyl, cycloalkyl or a saturated oxygen-containing heterocyclic group; R 2 and R 3 are each H, acyl or a saturated oxygen-containing heterocyclic group; and R 4 is a C 1-5 aliphatic hydrocarbon group which may be chloro-substituted if it is unsaturated) are prepared from the corresponding 17-ones and suitable reagents containing R 4 . They may also be obtained by microbiological hydroxylation of the corresponding 7-unsubstituted-17#-ols. In the products OH groups may be esterified or etherified and esters and ethers may be hydrolysed. 3,7α – bis – tetrahydropyranyloxy – #1,3,5(10)– estratrien-17-one is prepared from the corresponding 3,7-diol and dihydropyran. 3-Cyclopentyloxy – 7α – hydroxy – #1,3,5(10)-estratrien – 17- one is prepared from the same starting material and cyclopentyl bromide. The novel steroids possess a strong vaginotropic and a weak uterotropic action and they are suitable for treatment of estrogen deficiency phenomena, particularly for postmenopausal treatment of women. They may be made up into pharmaceutical compositions with suitable carriers.

GB41798/75A
1974-10-14
1975-10-13
7alpha-hydroxyoestradiols

Expired

GB1528796A
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE2449327A

DE2449327C2
(en)

1974-10-14
1974-10-14

7α-hydroxy-estradiols, processes for their preparation and medicaments containing them

DE19752535997

DE2535997A1
(en)

1975-08-08
1975-08-08
17-Alpha-ethynyl 1,3,5(10)-estratriene-3,7,17-beta-triol derivs. – having strong vaginotropic and wear uterotropic activity used in post-menopause period

Publications (1)

Publication Number
Publication Date

GB1528796A
true

GB1528796A
(en)

1978-10-18

Family
ID=25767825
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB41798/75A
Expired

GB1528796A
(en)

1974-10-14
1975-10-13
7alpha-hydroxyoestradiols

Country Status (23)

Country
Link

US
(1)

US4011314A
(en)

JP
(1)

JPS5165747A
(en)

AT
(1)

AT348695B
(en)

CA
(1)

CA1054143A
(en)

CH
(2)

CH619240A5
(en)

CS
(2)

CS205009B2
(en)

DD
(1)

DD125588A5
(en)

DK
(1)

DK135378C
(en)

ES
(1)

ES441784A1
(en)

FI
(1)

FI54603C
(en)

FR
(1)

FR2287908A1
(en)

GB
(1)

GB1528796A
(en)

HU
(1)

HU176715B
(en)

IE
(1)

IE42167B1
(en)

IL
(1)

IL48276A
(en)

NL
(1)

NL7512041A
(en)

NO
(1)

NO140824C
(en)

NZ
(1)

NZ178886A
(en)

PH
(1)

PH13802A
(en)

PL
(2)

PL101461B1
(en)

SE
(1)

SE405254B
(en)

SU
(2)

SU676170A3
(en)

YU
(2)

YU243975A
(en)

Cited By (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

WO2001060375A2
(en)

*

2000-02-15
2001-08-23
Hunter-Fleming Limited
Use of 7alpha-hydroxy-estradiol, 7alpha-hydroxy-dehydroepiandrosterone and 7alpha-hydroxy-pregnenolone derivatives for treating acute cellular degeneration

US6420353B1
(en)

1996-04-09
2002-07-16
Btg International Limited
Use of 7 α-substituted steroid to treat neuropsychiatric, immune or endocrine disorders

US7718639B2
(en)

2000-06-29
2010-05-18
Hunter-Fleming Limited
7-hydroxyepiandrosterone having neuroprotective activity

Families Citing this family (7)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB8327256D0
(en)

*

1983-10-12
1983-11-16
Ici Plc
Steroid derivatives

DE3741800A1
(en)

*

1987-12-07
1989-06-15
Schering Ag

17-halomethylene-estratrienes

US5861431A
(en)

*

1995-06-07
1999-01-19
Iotek, Inc.
Incontinence treatment

ATE501722T1
(en)

1999-09-30
2011-04-15
Harbor Biosciences Inc

THERAPEUTIC TREATMENT OF ANDROGEN RECEPTOR-RELATED DISEASES

SI1624878T1
(en)

*

2003-05-22
2007-02-28
Pantarhei Bioscience Bv
Use of compositions comprising an estrogenic component for the treatment and prevention of musculoskeletal pain

GB0403889D0
(en)

*

2004-02-21
2004-03-24
Univ Edinburgh
Uses of er-beta modulators

US7910755B2
(en)

2004-09-29
2011-03-22
Harbor Biosciences, Inc.
Stem cell expansion and uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3115444A
(en)

*

1962-01-22
1963-12-24
Olin Mathieson
Process for microbial hydroxylation of steroids containing aromatic alpha-rings

1975

1975-09-29
YU
YU02439/75A
patent/YU243975A/en
unknown

1975-09-30
DK
DK439975A
patent/DK135378C/en
active

1975-10-06
CS
CS756759A
patent/CS205009B2/en
unknown

1975-10-06
CS
CS756759A
patent/CS205010B2/en
unknown

1975-10-07
NZ
NZ178886A
patent/NZ178886A/en
unknown

1975-10-09
US
US05/621,136
patent/US4011314A/en
not_active
Expired – Lifetime

1975-10-10
IL
IL48276A
patent/IL48276A/en
unknown

1975-10-10
SU
SU752179006A
patent/SU676170A3/en
active

1975-10-10
DD
DD188799A
patent/DD125588A5/xx
unknown

1975-10-10
AT
AT775475A
patent/AT348695B/en
not_active
IP Right Cessation

1975-10-11
PL
PL1975183926A
patent/PL101461B1/en
unknown

1975-10-11
PL
PL1975206306A
patent/PL103989B1/en
unknown

1975-10-13
HU
HU75SCHE540A
patent/HU176715B/en
unknown

1975-10-13
FI
FI752836A
patent/FI54603C/en
not_active
IP Right Cessation

1975-10-13
SE
SE7511438A
patent/SE405254B/en
unknown

1975-10-13
PH
PH18192A
patent/PH13802A/en
unknown

1975-10-13
NO
NO753455A
patent/NO140824C/en
unknown

1975-10-13
GB
GB41798/75A
patent/GB1528796A/en
not_active
Expired

1975-10-14
NL
NL7512041A
patent/NL7512041A/en
not_active
Application Discontinuation

1975-10-14
CA
CA237,554A
patent/CA1054143A/en
not_active
Expired

1975-10-14
ES
ES441784A
patent/ES441784A1/en
not_active
Expired

1975-10-14
IE
IE2233/75A
patent/IE42167B1/en
unknown

1975-10-14
JP
JP50123743A
patent/JPS5165747A/en
active
Pending

1975-10-14
CH
CH1332375A
patent/CH619240A5/de
not_active
IP Right Cessation

1975-10-14
FR
FR7531364A
patent/FR2287908A1/en
active
Granted

1976

1976-09-27
SU
SU2179006A
patent/SU677666A1/en
active

1979

1979-10-31
CH
CH977879A
patent/CH619268A5/de
not_active
IP Right Cessation

1981

1981-12-15
YU
YU02942/81A
patent/YU294281A/en
unknown

Cited By (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US6420353B1
(en)

1996-04-09
2002-07-16
Btg International Limited
Use of 7 α-substituted steroid to treat neuropsychiatric, immune or endocrine disorders

WO2001060375A2
(en)

*

2000-02-15
2001-08-23
Hunter-Fleming Limited
Use of 7alpha-hydroxy-estradiol, 7alpha-hydroxy-dehydroepiandrosterone and 7alpha-hydroxy-pregnenolone derivatives for treating acute cellular degeneration

WO2001060375A3
(en)

*

2000-02-15
2002-04-04
Hunter Fleming Ltd
Use of 7alpha-hydroxy-estradiol, 7alpha-hydroxy-dehydroepiandrosterone and 7alpha-hydroxy-pregnenolone derivatives for treating acute cellular degeneration

US7718639B2
(en)

2000-06-29
2010-05-18
Hunter-Fleming Limited
7-hydroxyepiandrosterone having neuroprotective activity

Also Published As

Publication number
Publication date

YU294281A
(en)

1982-06-30

AT348695B
(en)

1979-02-26

FI54603B
(en)

1978-09-29

CS205009B2
(en)

1981-04-30

ATA775475A
(en)

1978-07-15

FI54603C
(en)

1979-01-10

PL101461B1
(en)

1978-12-30

FR2287908A1
(en)

1976-05-14

DK135378B
(en)

1977-04-18

CH619268A5
(en)

1980-09-15

YU243975A
(en)

1982-06-30

CH619240A5
(en)

1980-09-15

PL103989B1
(en)

1979-07-31

HU176715B
(en)

1981-04-28

IL48276A0
(en)

1975-12-31

PH13802A
(en)

1980-10-01

SU676170A3
(en)

1979-07-25

NO753455L
(en)

1976-04-20

CA1054143A
(en)

1979-05-08

JPS5165747A
(en)

1976-06-07

DK439975A
(en)

1976-04-15

SE7511438L
(en)

1976-04-15

SE405254B
(en)

1978-11-27

IL48276A
(en)

1979-03-12

AU8571075A
(en)

1977-04-21

NO140824B
(en)

1979-08-13

SU677666A3
(en)

1981-11-30

NZ178886A
(en)

1978-04-28

IE42167L
(en)

1976-04-14

SU677666A1
(en)

1981-11-30

IE42167B1
(en)

1980-06-18

DD125588A5
(en)

1977-05-04

ES441784A1
(en)

1977-04-01

FI752836A
(en)

1976-04-15

US4011314A
(en)

1977-03-08

NL7512041A
(en)

1976-04-20

CS205010B2
(en)

1981-04-30

FR2287908B1
(en)

1980-04-30

DK135378C
(en)

1977-10-03

NO140824C
(en)

1979-11-21

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Legal Events

Date
Code
Title
Description

1979-01-31
PS
Patent sealed [section 19, patents act 1949]

1983-05-18
PCNP
Patent ceased through non-payment of renewal fee

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